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PROTEIN S DEFICIENCY
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DeCS
Descriptor
English
:
Protein S Deficiency
Descriptor
Spanish
:
Deficiencia de Proteína S
Descriptor
Portuguese
:
Deficiência de Proteína S
Tree Number:
C15.378.100.800
C15.378.147.890
C15.378.925.800
Definition
English
:
An autosomal dominant disorder showing decreased levels of
plasma
protein S
antigen or activity, associated with
venous thrombosis
and
pulmonary embolism
.
PROTEIN S
is a vitamin K-dependent
plasma
protein that inhibits
blood clotting
by serving as a cofactor for activated
PROTEIN C
(also a vitamin K-dependent protein), and the clinical manifestations of its deficiency are virtually identical to those of
protein C deficiency
. Treatment with
heparin
for acute thrombotic processes is usually followed by
maintenance
administration
of coumarin drugs for the prevention of recurrent
thrombosis
. (From Harrison's Principles of
Internal Medicine
, 12th ed, p1511; Wintrobe's Clinical
Hematology
, 9th ed, p1523)
Indexing Annotation
English
:
a blood protein disord causing thromboses; DF:
PROTEIN S
DEFIC
History Note
English
:
95
Allowable Qualifiers
English
:
BL
blood
CF
cerebrospinal fluid
CI
chemically induced
CL
classification
CO
complications
CN
congenital
DI
diagnosis
DH
diet therapy
DT
drug therapy
EC
economics
EM
embryology
EN
enzymology
EP
epidemiology
EH
ethnology
ET
etiology
GE
genetics
HI
history
IM
immunology
ME
metabolism
MI
microbiology
MO
mortality
NU
nursing
PS
parasitology
PA
pathology
PP
physiopathology
PC
prevention & control
PX
psychology
RA
radiography
RI
radionuclide imaging
RT
radiotherapy
RH
rehabilitation
SU
surgery
TH
therapy
US
ultrasonography
UR
urine
VE
veterinary
VI
virology
Record Number:
32063
Unique Identifier:
D018455
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS